Selected abstracts on age-related factors which may predispose to carcinogenesis
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Selected abstracts on age-related factors which may predispose to carcinogenesis

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Published by U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, National Technical Information Service [distributor] in Bethesda, Md, Springfield, Va .
Written in English


  • Age -- United States.,
  • Carcinogenesis.

Book details:

Edition Notes

Other titlesAge related factors which may predispose to carcinogenesis.
StatementArthur G. Schwartz, consulting reviewer.
SeriesOncology overview
ContributionsSchwartz, Arthur G., International Cancer Research Data Bank.
The Physical Object
Paginationvii, 53 p. ;
Number of Pages53
ID Numbers
Open LibraryOL17550251M

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Aging may predispose to cancer by several mechanisms: (1) tissue accumulation of cells in late stages of carcinogenesis; (2) alterations in homeostasis, in particular, alterations in immune and endocrine system and (3) telomere instability linking aging and increased cancer risk. Abstract: Carcinogenic risk factors can be roughly divided into environmental may trigger off any of the steps involved in multistage carcinogenesis. 2) Ultraviolet light Genetic Factors Carcinogenesis is often sporadically observed, but sometimes concentrates in certain families. Aging may predispose to cancer at least by two mechanisms: tissue accumulation of cells in late stages of carcinogenesis and alterations in internal homeostasis, in particular, disturbances in. Abstract: Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many cancers particularly those of the colon display a form of genomic instability which may facilitate and speed up tumor initiation and development.

  Age-related DNA methylation changes at selected candidate genes have been reported (2–6) and several age-related DNA methylation sites have been linked to specific cancers (7–10). Large-scale identification of age-related CpG (arCpG) methylation sites may help provide understanding of both the underlying biological processes of aging and. The multistage (or multistep) model of carcinogenesis is the cornerstone of our understanding of how cancer is initiated. This model of sequential mutation driving carcinogenesis is generally considered to have originated with Nordling (), 1 who presented age-specific incidence data consistent with individual cells becoming cancerous after accumulating about seven mutational hits. aging. Materials and Methods: Fifteen male albino rats were classified into group A (4 months old), group B (18 months old) and group C (24 months old). Their stomach were dissected out and processed for light and electron microscope examination. Paraffin sections were stained with H & E, Masson's trichrome, PAS stain and immunohistochemically for detection of BCL-2 (antiapoptotic marker. This book will prove useful to oncologists and researchers in the field of carcinogenesis. Show less Advances in Biology of Skin, Volume VII: Carcinogenesis covers proceedings of the 15th Symposium on the Biology of Skin, held at the Oregon Regional Primate Research Center on April , , under the auspices of the University of Oregon.

Age-related differences in susceptibility to carcinogenesis—a quantitative analysis of empirical animal bioassay data. Environ Health Perspect Link, Google Scholar; Kilborn SH, Trudel G, Unthoff H. Review of growth plate closure compared with age at sexual maturity and lifespan in laboratory animals. Abstract Sixty-six patients with oral submucous fibrosis were followed-up for a period of 17 yr (median observation 10 yr) in Ernakulam District, Kerala, India. Oral cancer developed in five (%. Age-Related Macular Degeneration. Age-related macular degeneration (AMD or ARMD), which is also known as senile macular degeneration (SMD), is the principal cause worldwide of registered legal blindness among those aged over Almost two-thirds of the population over 80 years old will have some signs of AMD. Subject browse uses CABICODES which are CABI’s own classification codes for broad subjects that would be difficult to describe with keywords alone. Each database record is assig.